Every week of the NFL season ends with a Monday Night Football matchup on ESPN.
Read about the Monday Night Football betting predictions from all of last season.
MNF Odds and Analysis
Week 16 MNF Breakdown
It’s the changing of the guard on Monday Night Football out of the AFC East. For many years, the New England Patriots were the bully of the division. Now, there is a new divisional champion, as the Buffalo Bills have wrapped up the title.
The Bills will take on the Patriots on Monday Night Football and look to improve upon their playoff seeding status. Buffalo comes into this game listed at -7, despite being on the road at the Patriots.
No Playoffs for Patriots
Many seasons of postseason play came crashing to a halt in 2020 for the Patriots. At 6-8, the Patriots are officially eliminated from postseason contention. The Patriots have dropped back-to-back games and scored just a total of 15 points during those two games.
New England is one of the worst teams on offense, as it is scoring just 20.6 points per game. The passing game, led by Cam Newton, is throwing for just 185.4 yards per game. Newton has just five touchdowns via the pass on the season.
Bills Seeking Fifth Straight Win
The Buffalo Bills are looking to win their fifth straight game. The last time Buffalo lost was on Nov. 15 on a hail mary against the Cardinals. Before that, Buffalo had won three in a row.
The Bills lost to the Titans and Chiefs earlier in the season. Buffalo is scoring 29.1 points per game, which is fifth in the NFL. The passing game is second with 278.5 per game, and the run game is just over 100 per game.
Josh Allen has been great as the signal-caller, with 30 touchdown passes and nine interceptions.
Bills Take Out Frustrations
It’s not a fair fight this season. The Buffalo Bills are just a ton better than the New England Patriots.
Many years of frustration built up for Buffalo leads to an easy win on Monday night. Take the Bills to beat the Patriots.
Week 15 MNF Breakdown
Week 15 in the National Football League will finish with the Pittsburgh Steelers and Cincinnati Bengals meeting on Monday Night Football. The Steelers come into the game with a two-game lead in the AFC North with three games to go. Pittsburgh is 11-2.
The Cincinnati Bengals have had an awful 2020 season and are 2-10-1 coming into this game. The Steelers are big favorites in this game at -12.
Pittsburgh Needs to Run
The Steelers are having a tough time running the football and need to figure out a solution. The Steelers are averaging just 89.1 yards per game on the ground, which is 31st in the league.
James Conner has not been able to get any traction on the ground. But the Bengals defense could be the cure for that.
The passing game has been solid for the Steelers, with Ben Roethlisberger as signal-caller. He has connected with JuJu Smith-Schuster, Dionte Johnson and Chase Claypool for over 600 yards apiece on the season. Claypool leads the team with eight touchdowns.
Bengals Struggles Continue
The Bengals were competitive with Joe Burrow at quarterback. Then, Brandon Allen came in after Burrow’s season-ending injury, and now it’s Ryan Finley.
Cincinnati’s two wins this season came over the Jaguars on Oct. 4 and the Titans back in early November. Since the last win for Cincinnati, it is averaging just 10 points per game.
Giovanni Bernard fumbled on his first carry in the loss to the Cowboys on Sunday. He was projected to have a bounce-back week and finished with just eight rushing yards. He has just 261 yards and two touchdowns on the season.
Steelers Should Bounce Back Big
The Steelers should be able to bounce back from back-to-back losses. Sure, this game is in Cincinnati, but playing a third-string quarterback is not a great situation. The Bengals are ready to finish their season.
The Steelers are ready to bounce back in a big way here. Take the Steelers to take this game by double-digits and get their 12th win of the season on Monday Night Football.
Week 14 MNF Breakdown
The Baltimore Ravens and Cleveland Browns will square off on Monday Night Football to wrap up Week 14 of the NFL season. The Baltimore Ravens come into the game with a 7-5 record, which ties them with the Raiders, a game out of the postseason in the AFC race. Baltimore is coming off a win on Tuesday over the Dallas Cowboys.
For Cleveland, they are atop of the AFC Wild Card standings. The Browns are 9-3 and a game ahead of both the Dolphins and the Colts. Cleveland is two games behind Pittsburgh in the AFC North race.
This game is listed at pick ’em for Monday night.
Mayfield Heating Up
Baker Mayfield is heating up for the Cleveland Browns. Though the team is known for its ability to run the football, Mayfield opened up the field with four touchdown passes in the blowout win over the Titans. Mayfield is 58 yards shy of 2,500 on the season, with 21 touchdowns. This is being done without Odell Beckham Jr, who is out for the season.
The run game is where Cleveland makes its money. Kareem Hunt and Nick Chubb have combined to run the ball more than 300 times for over 1,500 yards and a combined 11 touchdowns.
Ravens Hanging On
The Ravens have had an interesting season. The team missed time with COVID-19 problems and has had games moved all over this season. Ravens quarterback Lamar Jackson missed their Week 12 game but came back and rushed for the first touchdown to start the game against Dallas.
The Ravens are also a team that loves to run the football. Baltimore has a three-headed monster with Gus Edwards, J.K. Dobbins and Mark Ingram, as well as Jackson. The Ravens are also hoping to get their top target, tight end Mark Andrews, back for this game.
Great AFC North Affair
There is no doubt; both teams have a ton on the line for this game. First and foremost, the Ravens need the win to keep their playoff chances alive.
The Browns still have a shot at the division title and would also love to send a division rival packing. Look for an awesome Monday Night Football affair in Week 14.
Week 13 MNF Breakdown
The NFL will see a pair of games for Monday Night in Week 13. The original Monday Night Football game for the week was the Buffalo Bills at the San Francisco 49ers. That will now be the second game.
The first game of the night features the Washington Football Team on the road at the Pittsburgh Steelers. The Steelers are -10 at home, while Buffalo is -2.5 on the road in these two games.
Washington Football Team at Pittsburgh Steelers
Washington is in a battle with the rest of the NFC East for the divisional title. With just four wins, they are right in the mix.
Washington is coming off a Thanksgiving Day win over Dallas. Quarterback Alex Smith has come in and been steady. While his numbers are not great, he keeps the offense moving.
Pittsburgh went into its Week 12 game against Baltimore with a 10-0 record. The Steelers are elite on both sides of the football.
Pittsburgh is scoring 29.8 points per game and allowing just 17.4 per game. The Steelers are looking to keep the top spot in the AFC and earn a first-round bye.
Buffalo Bills at San Francisco 49ers
Josh Allen and the Buffalo Bills are looking to keep their lead in the AFC East. While not playing great football in a Week 12 win over the Chargers, the Bills picked up their eighth win of the season.
Buffalo is 10th in the league in offense with just over 28 points per game. Allen has been excellent, with 22 touchdown passes and eight interceptions on the season.
For San Francisco, a home win would push it back to .500, though this won’t be a typical home game since it will be played in Arizona. The 49ers’ home stadium is in Santa Clara, Calif., which has banned contact sports, prompting the move of this contest to the Arizona Cardinals’ home stadium.
The 49ers beat the Rams on Sunday to stay alive in the NFC West race. The 49ers have been stung by the injury bug, including quarterback Jimmy Garoppolo. Nick Mullens has come in and thrown for over 1,600 yards this season.
Fun Monday Football
These should be two great football games. Expect both favorites to win these games, and a couple of AFC division races moving even closer to wrapping up for the season.
Week 12 MNF Breakdown
Week 12 of the National Football League season will come to an end with the Seattle Seahawks visiting the Philadelphia Eagles on Monday Night Football. The Eagles are 3-6-1 on the season but right in the mix in the NFC East. All four teams in the division have three wins coming into Week 12, so interesting games are coming down the stretch.
For the Seattle Seahawks, they are 7-3 on the season. Seattle is tied with the Rams at the top of the NFC West entering the week. Seattle is coming off a big win over Arizona in Week 11.
The Seahawks come into this game as six-point favorites on the road at the Eagles.
Eagles Turning Football Over Too Much
The Eagles have just continued to beat themselves with turnovers. Quarterback Carson Wentz has been the main culprit with 14 interceptions on the season.
The Eagles have been one of the worst offensive teams in the league and are coming off back-to-back games with just 17 points in each. Miles Sanders is back for the Eagles, but his three touchdowns and two fumbles lost do not provide a ton of extra hope.
Seattle Offense Exploding
The Seahawks have been an offensive machine this season. Seattle scored 28 points in its win over Arizona, but before that, it was averaging just shy of 30 per game.
Quarterback Russell Wilson has been tremendous, with more than 2,980 passing yards and 30 touchdowns on the season. D.K. Metcalf has emerged as a top receiver in the league with more than 860 yards and nine touchdowns.
Eagles Struggle to Stop Seahawks
In the end, the Eagles are going to have a tough time slowing down the Seattle offense. Then, Wentz and company are going to need to be great to keep up.
That does not appear to be the most likely result for Monday Night Football.
Week 11 MNF Breakdown
The Monday Night Football game to wrap up Week 11 is projected to be a really good one. The Los Angeles Rams will be on the road at the Tampa Bay Buccaneers.
Both teams are in an NFC Wild Card spot, and both are in dog fights to win their divisions. Tampa Bay is at home in this game and comes in as a three-point favorite. The total for this game opened at 47.
Buccaneers Looking to Keep Scoring
Tampa Bay scored 46 points in its road win at Carolina last weekend. That was the Bucs’ highest output of the season, which came a week after mustering just a field goal in a loss at home to the Saints.
On the season, the Buccaneers are tied for sixth in the league with nearly 30 points per game. The passing attack is averaging nearly 265 yards per game, while they are rushing for an additional 103.9 per game. Ronald Jones is coming off a monster game against the Panthers, including a 99-yard touchdown run.
Rams Looking to Keep Pace
The Rams are tied with Seattle and Arizona at the top of the NFC West after coming away with a monster win at home over the Seahawks last weekend. Los Angeles has dropped games at Buffalo, San Francisco, and Miami this season. The road wins for the Rams this season are at the Eagles and Washington.
Jared Goff leads the team offensively with 13 passing touchdowns and six interceptions. Malcolm Brown leads the running game with five touchdowns on the ground.
Monday Finishes Strong
This is a great Monday Night Football matchup. Both of these teams have playoff potential, and we expect a great game. The Buccaneers at home seem tough to beat, but we will find out when the dust settles Monday night.
Week 10 MNF Breakdown
It’s the Minnesota Vikings and the Chicago Bears on Monday Night Football, which will finish the slate for Week 10 of the NFL season. The Vikings come into the game fresh off their second straight win and are 3-5 on the season.
Chicago has dropped three in a row and is 5-4 on the season. Both teams are chasing the Green Bay Packers in the NFC North. The Vikings are three-point favorites despite being on the road in this game.
Vikings Heating Up
The Vikings started 1-5 on the season but have won back-to-back games, topping the Packers and the Lions. In those two games, the offense scored 31 points per game. Previously, the Vikings were scoring just over 26 per game.
Dalvin Cook has been an absolute monster for the Minnesota offense. Cook scored four rushing touchdowns against the Packers, then rushed for 206 yards and two scores against the Lions.
On the season, the running back is helping his offense to the third-most rushing yards per game in the league. Minnesota needs him, as it is 30th in defense, allowing nearly 423 yards per game.
Chicago Needs Some Life
The Bears were 5-1 on the season but have since dropped games to the Rams, Saints and Titans. In those three games, the Bears offense has scored just 16.6 points per game. Chicago will enjoy its bye week after this before going to Green Bay for another divisional test on Nov. 29.
Chicago will have to hang its hat on the defensive side of the ball. The offense is one of the worst in the league and has the fewest rushing yards of any team.
Defensively though, the Bears are in the Top 10 in nearly everything. Chicago is allowing just 218 yards per game via the pass and is seventh in points allowed, with 21.1 per game.
Monday Night Thriller
The Windy City is going to be ready for this one. Chicago needs a win to stay ahead of Minnesota and in a good spot for the postseason.
On the other side, the Vikings could use a massive win, and they would be right back in the playoff picture. Minnesota as a favorite on the road seems odd, but Vegas knows what it is talking about.
Week 9 MNF Breakdown
The Monday Night Football game to finish Week 9 of the National Football League season will feature two teams struggling big time in 2020. The New England Patriots are on the road at the New York Jets.
The Patriots and Jets are in third and fourth place in the AFC East, respectively. The Patriots are 2-5 on the season, while the Jets are 0-8. New England comes into this game listed as a touchdown favorite.
Cam Newton has come to New England, and things have not been great for the signal-caller. The former Panthers quarterback has thrown just two touchdowns this season compared to seven interceptions. Rex Burkhead and N’Keal Harry are the top two threats for New England, with Burkhead two touchdowns on the ground.
The Jets have dropped their first eight games of the season and played just two games within double-digits. Those games came in an 18-10 loss to the Bills and a nine-point setback at home to the Broncos.
The Jets are the worst offense in the league, with 291.6 yards per game and 12.1 points per game. Defensively, the Jets are 25th in the league, allowing 29 points per game.
Sam Darnold is likely to miss this game with a shoulder injury. The quarterback for New York has thrown six interceptions with just three touchdowns this season. The top threat for the Jets on offense is veteran receiver Jamison Crowder.
The last time these two teams played, the Patriots blanked the Jets 33-0 just over a season ago. How will the 2020 version go?
Week 8 MNF Breakdown
Week 8 of the NFL season will come to completion with the Monday Night Football game featuring the Tampa Bay Buccaneers on the road against the New York Giants. Despite being on the road for this game, the Buccaneers are big favorites. Tampa Bay is listed as a 12.5-point favorite, with a total set at 44.5.
Brady Leading Buccaneers
Veteran quarterback Tom Brady has come over to Tampa Bay and won five of his first seven starts. The Buccaneers have seen Brady throw for 18 touchdowns and just four interceptions in those seven games.
Chris Godwin and Mike Evans are one of the best duos of receivers in the league, and soon Tampa Bay will be adding Antonio Brown. Evans leads the team with six touchdown receptions.
The Buccaneers are third in the league with over 31 points per game. Defensively, Tampa Bay is underrated, as the Buccaneers are allowing just 20.3 per game. In the last two games, the Buccaneers have held the Packers and Raiders to a total of just 30 points.
Giants Seeking Win No. 2
The New York Giants have just one win on the season. In the NFC East, that’s still in the division race, but overall in the league, they are one of the worst teams in the league.
The lone win for the Giants was in Week 6 over Washington. Last week, the Giants lost a tough 22-21 game in Philadelphia.
Daniel Jones has had a tough time not throwing the ball away this season. The quarterback out of Duke has just five touchdown passes and seven interceptions.
One of the bright spots for the Giants has been the emergence of Darius Slayton. Slayton leads the team with 429 receiving yards and three touchdowns. New York is without their top running back Saquon Barkley for the rest of the season.
Tampa Bay Looks To Run Away
One thing about Brady and his teams – they don’t usually slow down and quit. While the game is in New York – that’s not an issue for Brady. Look for Tampa Bay to run away and hide in this game on Monday Night Football.
Week 7 MNF Breakdown
The National Football League will see a great end to Week 7, as two contenders in the NFC get together in Los Angeles. The Chicago Bears, who lead the NFC North, will take on the Los Angeles Rams.
The Bears are a half-game ahead of Green Bay with their 5-1 record. Chicago is coming off a thrilling win at Carolina.
The Rams are 4-2 and trail Seattle in the NFC West. Los Angeles is coming off a close loss in San Francisco on Sunday night. The Rams are -5.5 for this game, with a total of 46.
Jared Goff is ready to bounce back in a big way. That will not be an easy task with the tough Chicago defense. The air attack for the Rams has seen Goff throw for 1,570 yards and 10 touchdowns this season.
Robert Woods continues to be steady for the Rams, as he leads the team with 329 receiving yards. The Rams are picking up nearly 390 yards per game, which is 11th in the league.
For the Bears, many call them the most fortunate team in the NFL. Despite that, coach Matt Nagy and his team are 5-1.
Chicago has been great on the defensive side of the ball, allowing just 19.3 points per game. On the offensive side, Nick Foles took over for Mitchell Trubisky and has been average. Foles has an 80.4 rating, with six touchdowns and four interceptions.
This is going to be a tough task for the tough Bears defense to keep up with the Rams offense. There is no doubt Sean McVay is going to open up his bag of tricks in a game the Rams need to win. Expect fireworks in Los Angeles!
Week 6 MNF Breakdown
There are a pair of Monday Night Football games to wrap up the slate of Week 6. The original game put the Arizona Cardinals on the road at the Dallas Cowboys. Both teams seem to be heading in different directions, even though both won in Week 5.
The Cardinals are 3-2 and seem to be trending upwards with a young, athletic quarterback. Meanwhile, Dallas is 2-3 and leading the NFC East but has lost its starting quarterback for the remainder of the season. The Dallas Cowboys are -3 in this game over the Arizona Cardinals.
The Cowboys come into the game as one of the best offenses in all of the NFL. But, the million-dollar question will be, can Andy Dalton keep up that attack with Dak Prescott sidelined for the rest of the campaign?
Dallas is throwing for more than 367 yards per game and rushing for over 100 more. Dallas is scoring 32.6 points per game as a team. The bell-cow running back for Dallas, Ezekiel Elliott, will get even more opportunities in this offense without Prescott. Elliott has five touchdowns via the run game.
In his second season as the signal-caller for Arizona, Kyler Murray has been pretty sharp via the passing game and on the ground. Murray, of course, would like to have back his 1.5 interceptions per game, but his Cardinals are scoring just shy of 30 points per game. Arizona will try to get running back Kenyan Drake back more involved, as he has just two touchdowns on the season.
The first game of the night is a postponement of the originally scheduled Thursday Night Football game. With Buffalo playing Tennessee on Tuesday to wrap up Week 5, it was not able to play Thursday, so the game was instead moved to Monday. The point spread for this game has yet to be released.
Week 5 MNF Breakdown
The final game in Week 5 of the NFL schedule pits the Los Angeles Chargers against the New Orleans Saints. Neither team has gotten off to a great start this season, as the Chargers are 1-3, and New Orleans is 2-2. The Saints come into this game as the favorite, as New Orleans is -7.5 in this game, with a total sitting at 51.
The Saints are hoping to get their stud receiver Michael Thomas back for this game. His status is unknown, as he has missed the last two games with an injury.
Since Thomas has been out, Emmanuel Sanders has taken over some of the load. Sanders has caught 14 passes for 182 yards and two touchdowns. The running game has been tremendous for the Saints. Alvin Kamara has four rushing touchdowns in 2020.
On the other side, the Los Angeles Chargers have also seen a solid running game. Austin Ekeler leads the way with 49 carries, 248 yards, and a touchdown, though he’s going to be sidelined for a few weeks after a Week 4 injury.
Keenan Allen also has just one touchdown but has 32 receptions on the season. The lone win for the Chargers this season came in Week 1 against the Bengals. Since then, the losses have come to Kansas City, Carolina, and Tampa Bay.
The Saints are going to want to march the football down the field with Kamara, then give Drew Brees the ability to spray the ball. The Chargers do not seem to have the defense to put a stop to that, and it seems their losing streak is in jeopardy of continuing on Monday night.
Week 4 MNF Breakdown
Week 4 of the NFL season will end with a Monday Night Football affair between a winless team and an unbeaten team. The Atlanta Falcons will head to Lambeau Field in Green Bay to take on the Packers.
The Falcons have been the talk of the league with back-to-back big leads lost in the fourth quarter, which turned to losses. After losing in Week 1 to the Seahawks, the Falcons dropped a game in Dallas, followed by a home loss to Chicago. Atlanta is allowing teams to score 36 points per game through the first three weeks.
The Packers are on the opposite side of that. Green Bay is scoring 40.6 points per game, with wins over the Vikings, Lions and Saints. The Packers are tied at the top of the NFC North with the Bears. Green Bay will take their bye week in Week 5 following this game.
The key, of course, will be quarterback play. Matt Ryan for Atlanta has thrown seven touchdowns and two interceptions, while Aaron Rodgers keeps dominating with nearly 890 yards and nine touchdowns through the air.
The Packers open this game as a 7.5-point favorite at home, with an ultra-high total of 58.
Week 3 MNF Breakdown
We have two of the top teams in all of the NFL getting together for the final game in Week 3 on Monday night. We also have two of the top quarterbacks in the league getting together. The Kansas City Chiefs are at the Baltimore Ravens, with both teams coming in with 2-0 records.
The Chiefs are 2-0 after their overtime win on Sunday over the Chargers. Patrick Mahomes has tossed for over 500 yards this season with five touchdown passes.
Rookie running back Clyde Edwards-Helaire has been brilliant on the ground for Kansas City with nearly 90 yards per game in his first two games. Tyreek Hill is averaging five receptions per game and has 145 yards and two touchdowns as well.
Kansas City is tied with the Las Vegas Raiders atop the AFC West.
For Baltimore, reigning league MVP Lamar Jackson is once again the story. Jackson has completed 38 out of 49 passes for 479 yards and four touchdowns in his first two games. Jackson, along with Mahomes, has yet to throw an interception.
His top target has been tight end Mark Andrews, with six receptions and two touchdowns in 2020. On the ground, Mark Ingram has a touchdown on 19 carries and 84 yards. The Ravens and Steelers are both unbeaten atop the AFC North.
This should be a great game, and the Baltimore home field could prove to be the difference-maker. Despite having no home fans, Baltimore is looking to get revenge on the Super Bowl champions, and also the regular-season meeting nearly a year ago that Kansas City won 33-28.
Week 2 MNF Betting Breakdown
The biggest thing to watch this week for the Saints is the status of injured wide receiver Michael Thomas. The All-Pro suffered a high ankle sprain late in the Saints’ Week 1 win and may be out for the game against the Raiders.
Brees threw for just 160 yards in the win over Tampa Bay, but he did throw for two scores. Tight end Jared Cook (five catches, 80 yards) had the biggest day catching the ball for New Orleans while running back Alvin Kamara (five catches, 51 yards, one TD) and newly-acquired wide receiver Emmanuel Sanders (three catches, 16 yards, one TD) found the end zone.
The Saints picked off Tom Brady twice, including a pick-six for Janoris Jenkins. They held the Buccaneers to 3.3 yards per rush.
The Raiders had a monster game on the ground in Carolina as Josh Jacobs scored thee times. The second-year back ran 25 times for 93 yards and caught four passes for 46 yards.
Quarterback Derek Carr was 22-for-30 for 239 yards and a touchdown. Tight end Darren Waller had six catches for 35 yards, while rookie wide receiver Henry Ruggs III had three catches for 55 yards.
The Raiders defense didn’t force a turnover. They allowed Panthers wide receiver Robby Anderson to haul in 115 reception yards while Christian McCaffrey ran for 96 yards on 23 carries.
MNF Betting Breakdown
If the Saints can stop the run as they did in Week 1, the Raiders could be in for a long night. Carr didn’t have a turnover in the opener after leading the NFL in fumbles last year and throwing eight interceptions.
The home dog is tempting in this one, but the over is more appealing, especially if it stays under 50.
Best Monday Night Football Betting Sites
There are several options based on your location in the US. DraftKings, PointsBet, FanDuel, William Hill, and BetMGM are among the US sportsbooks offering MNF lines. As a prime-time game, many will also offer game and player props and could have odds boosts and special offers.
Monday Night Football Betting Tips
As a stand-alone game and the final game of the week, the Monday Night game can be highly-anticipated. Teams usually have an extra day to prepare and get players healthy. Make sure you look at injury reports to see if that extra day helps bring important players back to the field.
Look at schedules and see how much time off the teams had since their previous game, especially the road team. This can make a big difference in finding value to bet on if one team has an extra day off or is coming off a bye week.
As the final game of the week, some bettors will try to make up for a bad weekend on the MNF game. Look at the line at the beginning of the week and see how it moves with the public and what adjustments are made on Monday. This is a good way to bet like a sharp and go against the public.
Where to Watch Monday Night Football
Monday Night Football airs on ESPN at 8:15 p.m. ET every Monday from Sept. 7 to Dec. 28. There is no Monday Night Football game for Week 17, the final game of the NFL season. To make up for that, ESPN gets a Monday Night doubleheader in Week 1.
The MNF booth broadcast crew is new in 2020, with Steve Levy on play-by-play alongside analysts Brian Griese and Louis Riddick. Lisa Salters has been the sideline reporter since 2012 and returns to that role this season.
Before the game, ESPN has a pre-game show, Monday Night Countdown, starting at 7:30 p.m. Countdown is hosted by Suzy Kolber with Randy Moss, Steve Young, and Booger McFarland as analysts.
Every MNF game can be seen on ESPN and on the Watch ESPN App with a cable or satellite subscription. Most streaming services also carry ESPN in subscription packages.
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Monday Night Football Schedule 2020
- Week 2 – Sept. 21: New Orleans Saints at Las Vegas Raiders
- Week 3 – Sept. 28: Kansas City Chiefs at Baltimore Ravens
- Week 4 – Oct. 5: Atlanta Falcons at Green Bay Packers
- Week 5 – Oct. 12: Los Angeles Chargers at New Orleans Saints
- Week 6 – Oct. 19: Arizona Cardinals at Dallas Cowboys
- Week 7 – Oct. 26: Chicago Bears at Los Angele Rams
- Week 8 – Nov. 2: Tampa Bay Buccaneers at New York Giants
- Week 9 – Nov. 9: New England Patriots at New York Jets
- Week 10 – Nov. 16: Minnesota Vikings at Chicago Bears
- Week 11 – Nov. 23: Los Angeles Rams at Tampa Bay Buccaneers
- Week 12 – Nov. 30: Seattle Seahawks at Philadelphia Eagles
- Week 13 – Dec. 7: Buffalo Bills at San Francisco 49ers
- Week 14 – Dec. 14: Baltimore Ravens at Cleveland Browns
- Week 15 – Dec. 21: Pittsburgh Steelers at Cincinnati Bengals
- Week 16 – Dec. 28: Buffalo Bills at New England Patriots
Make sure to keep up the results of all Monday Night Football games, the knowledge could come in handy for 2021 Super Bowl betting!